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I recently bought a 6300, and there's some interference while talking on the phone, similar to what happens when you stand next to a speaker, like a buzzing sound of some sort.
If this happens on all calls, it sounds like your phone is defective. You might try making sure you are running the latest firmware and, if not, see if installing the latest firmware helps, but it sounds like a hardware problem to me.
Hmm ok, I'll have to go back into the o2 shop and ask for either a replacement or another unit to see if it's the **bleep**py network or the phone itself...